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Lymphangioleiomyomatosis
- Often by premenopausal patients, but also (rarer) in adolescence.The pulmonary manifestation is most common: pneumothorax, dyspnea.Abdominal symptoms include chronic complaints, abd...
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Gene regulator in brain's executive hub tracked across lifespan -- NIH study
- For the first time, scientists have tracked the activity, across the lifespan, of an environmentally responsive regulatory mechanism that turns genes on and off in the brain's executive hub. Among key findings of the study by National Institutes of Health scientists: genes implicated in schizophrenia and autism turn out to be members of a select club of genes in which regulatory activity peaks during an environmentally-sensitive critical period in development.
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NIH study uncovers probable mechanism underlying resveratrol activity
- National Institutes of Health researchers and their colleagues have identified how resveratrol, a naturally occurring chemical found in red wine and other plant products, may confer its health benefits.
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NCCAM's Advisory Council welcomes six new members
- The National Center for Complementary and Alternative Medicine (NCCAM) welcomes six new members to the National Advisory Council for Complementary and Alternative Medicine. The council serves as the principal advisory body to NCCAM, the lead federal agency for research on complementary medicine, and a component of the National Institutes of Health.
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The NIH urges women to protect their heart health
- As part of American Heart Month, on Wednesday, Feb. 8, 2012, the National Heart, Lung, and Blood Institute's (NHLBI's) The Heart Truth campaign, with the support of the Foundation for the National Institutes of Health (FNIH), will showcase its signature event, the Red Dress Collection 2012 at Mercedes-Benz Fashion Week in New York City.
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NIH-funded HIV clinical research sites to join pediatric tuberculosis vaccine study
- Several U.S. government-funded HIV/AIDS clinical research sites in Africa will join other collaborators in an ongoing clinical trial testing an investigational tuberculosis (TB) vaccine in infants at risk for TB infection. "We are pleased to be able to tap into our existing HIV/AIDS clinical research infrastructure to help test promising investigational vaccines against TB," said NIAID Director Anthony S. Fauci, M.D. The sites are funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
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Award-winning physician appointed deputy director at NIMHD
- The National Institute on Minority Health and Health Disparities (NIMHD) announced today the appointment of M. Roy Wilson, M.D., M.S., an award-winning physician and academic administrator, as NIMH's Deputy Director Strategic Scientific Planning and Program Coordination. NIMHD is part of the National Institutes of Health.
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New NIH fact sheet explains test for diabetes, prediabetes
- A new fact sheet from the National Institutes of Health explains the A1C test, a widely used and important test to diagnose type 2 diabetes and prediabetes, and to monitor blood glucose levels of people with type 1 and type 2 diabetes.
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NIH launches trials to evaluate CPR and drugs after sudden cardiac arrest
- The National Institutes of Health has launched two multi-site clinical trials to evaluate treatments for out-of-hospital cardiac arrest. One will compare continuous chest compressions (CCC) combined with pause- free rescue breathing to standard cardiopulmonary resuscitation (CPR), which includes a combination of chest compressions and pauses for rescue breathing. The other trial will compare treatment with the drug amiodarone, another drug called lidocaine, or neither medication (a salt-water placebo) in participants with shock-resistant ventricular fibrillation, a condition in which the heart beats chaotically instead of pumping blood.
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NIH Study shows caffeine consumption linked to estrogen changes
- Asian women who consumed an average of 200 milligrams or more of caffeine a day -- the equivalent of roughly two cups of coffee -- had elevated estrogen levels when compared to women who consumed less, according to a study of reproductive age women by researchers at the National Institutes of Health and other institutions.
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Elevated risk factors linked to major cardiovascular disease events across a lifetime
- In one of the largest-ever analyses of lifetime risks for cardiovascular disease (CVD), researchers have found that middle-aged adults who have one or more elevated traditional risk factors for CVD, such as high blood pressure, have a substantially greater chance of having a major CVD event, such as heart attack or stroke, during their remaining lifetime than people with optimal levels of risk factors. This National Institutes of Health-supported study used health data from 257,384 people and was the first to look simultaneously at multiple risk factors for CVD across age, sex, race, and birth generation.
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High animal fat diet increases gestational diabetes risk
- Women who consumed a diet high in animal fat and cholesterol before pregnancy were at higher risk for gestational diabetes than women whose diets were lower in animal fat and cholesterol, according to researchers at the National Institutes of Health and Harvard University.
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NIH kidney disease experts urge: Get Involved
- A new series of free tools and resources will help community groups increase awareness about steps to prevent kidney disease or improve management. The online resource is sponsored by the National Institutes of Health's National Kidney Disease Education Program (NKDEP).
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Treatment of silent acid reflux does not improve asthma in children, NIH study finds
- Adding the acid reflux drug lansoprazole to a standard inhaled steroid treatment for asthma does not improve asthma control in children who have no symptom of acid reflux, according to a new study funded in part by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health.
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Correction: RFA-AI-12-002 Limited Competition - Women's Interagency HIV Study (WIHS-V)(U01)
- Notice NOT-AI-12-025 from the NIH Guide for Grants and Contracts
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Reminder of Requirements for RFA-HL-12-004 Maximizing the Scientific Value of the NHLBI Biologic Specimen Repository: Scientific Opportunities (R21)
- Notice NOT-HL-12-010 from the NIH Guide for Grants and Contracts
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Notice of Funding Opportunity for Ancillary/Collaborative Studies for the NHLBI Progenitor Cell Biology Consortium
- Notice NOT-HL-12-011 from the NIH Guide for Grants and Contracts
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Frequently Asked Questions (FAQs) for RFA-MH-13-022 - Competitive Revision Applications for Research on Neural Processes Underlying Sex Differences Related to Risk and Resilience for Mental Illness (P50)
- Notice NOT-MH-12-016 from the NIH Guide for Grants and Contracts
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Extension of Comment Period on the Office of Laboratory Animal Welfare Position Statements
- Notice NOT-OD-12-042 from the NIH Guide for Grants and Contracts
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Resource support for Consortiums for HIV/AIDS and Alcohol-Related Outcomes Research Trials (CHAART) U24
- Funding Opportunity RFA-AA-12-010 from the NIH Guide for Grants and Contracts. This funding opportunity (FOA) issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) solicits Cooperative Agreement (U24) applications to continue to support the currently NIAAA-funded " Consortiums for HIV/AIDS and Alcohol-Related Research Translation (CHARRT) or Alcohol and HIV/AIDS Centers (P01, P50, P60) to enhance their capacity to carry out multidisciplinary, transdisciplinary, and/or integrative behavioral and biological research. The CHARRT consortiums and Alcohol and AIDS Centers aim to accelerate specific areas of research related to the goals of improving HIV/AIDS treatment among infected individuals affected by alcohol use, and to prevent the transmission of HIV within U.S. and international populations. Specifically, the three primary goals of the U24 resource cores are to: 1) increase levels of collaboration between existing research projects focusing on alcohol and HIV/AIDS, in particular to improve their capacity to carry out translational, operational, or implementation science research studies; and/or 2) provide enhanced capacity to evaluate the impact of alcohol use and HIV within longitudinal research designs, with particular attention to aging; and/or 3) facilitate the implementation of alcohol and HIV/AIDS interventions within targeted populations at greatest risk within the United States).
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Partnerships for Development of Vaccine Technologies (R01)
- Funding Opportunity RFA-AI-12-014 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) issued by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), invites research applications for projects focused on preclinical development of candidate technologies (including adjuvants) that would improve vaccine effectiveness and/or simplify vaccine delivery to patient populations during a natural outbreak of an infectious disease or following the intentional release of an infectious agent. Applications must include a Product Development Strategy attachment and demonstrate substantive investment by at least one industrial participant.
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Modeling Social Behavior (R01)
- Funding Opportunity RFA-GM-13-006 from the NIH Guide for Grants and Contracts. This FOA, issued by the National Institute of General Medical Sciences (NIGMS) and the National Institute of Mental Health (NIMH), solicits applications for developing and testing innovative theories and computational, mathematical, or engineering approaches to deepen our understanding of complex social behavior. This research will examine phenomena at multiple scales to address the emergence of collective behaviors that arise from individual elements or parts of a system working together. This FOA will support research that explores the often complex and dynamical relationships among the parts of a system and between the system and its environment in order to understand the system as a whole.
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Grand Challenges in Global Mental Health: Integrating Mental Health into Chronic Disease Care Provision in Low- and Middle-Income Countries (R01)
- Funding Opportunity RFA-MH-13-040 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks research project grant (R01) applications that promote the establishment of an evidence base on contextually relevant, cost-effective integrated care interventions for the treatment of patients with co-morbid mental and chronic physical illnesses in low- and middle-income countries (LMICs). Specifically, this FOA will support research that builds on existing chronic disease care and treatment platforms to incorporate management of mental illness, employs a multi-disease care management approach with potentially high impact for improving patient- and system-level outcomes (e.g., patient morbidity and functioning; improved diagnosis of mental illness among patients with chronic medical illnesses; decreased cost to the health care system; improved care coordination), and establishes feasible methods for multi-disease management in LMICs.
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Limited Competition for Continuation of the NIH Exploratory Trials in Parkinson's Disease (NET-PD): Coordinating and Statistical Centers (U01)
- Funding Opportunity RFA-NS-13-001 from the NIH Guide for Grants and Contracts. The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for a limited competition Funding Opportunity Announcement (FOA) utilizing a Cooperative Agreement (U01) to provide continuing support for Clinical and Data Coordinating Centers in the NIH Exploratory Trials in Parkinson's Disease network (NET-PD). The goal of this initiative is to support completion of NET-PD's current ongoing clinical trials.
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Limited Competition for Continuation of the NIH Exploratory Trials in Parkinson's Disease (NET-PD): Clinical Sites (U10)
- Funding Opportunity RFA-NS-13-002 from the NIH Guide for Grants and Contracts. The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for a limited competition Funding Opportunity Announcement (FOA) utilizing a Cooperative Agreement (U10) to provide continuing support for Clinical Sites in the NIH Exploratory Trials in Parkinson's Disease network (NET-PD). The goal of this initiative is to support completion of NET-PD's current ongoing clinical trials.
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PHS 2012-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
- Funding Opportunity PA-12-088 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) issued by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA) and the Administration for Children and Families (ACF) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) grant applications. United States SBCs that have the research capabilities and technological expertise to contribute to the R and D mission(s) of the NIH, CDC, FDA or ACF awarding components identified in this FOA are encouraged to submit SBIR grant applications in response to identified topics (see PHS 2012-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, FDA and ACF
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PHS 2012-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
- Funding Opportunity PA-12-089 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) issued by the National Institutes of Health (NIH) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) grant applications. United States SBCs that have the research capabilities and technological expertise to contribute to the R and D mission(s) of the NIH awarding components identified in this FOA are encouraged to submit STTR grant applications in response to identified topics (see PHS 2012-2 SBIR/STTR Program Descriptions and Research Topics for NIH.)
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New Technologies for Viral Hepatitis SBIR (R43/R44)
- Funding Opportunity PA-12-090 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to respond to the Combating the Silent Epidemic of Viral Hepatitis: U.S. Department of Health and Human Services Action Plan for the Prevention, Care and Treatment of Viral Hepatitis (Viral Hepatitis Action Plan) which was released on May 12, 2011 (http://www.hhs.gov/ash/initiatives/hepatitis/). SBCs are encouraged to propose SBIR grant applications to develop resources, research tools, instrumentations, biomarkers, devices, drugs or new and innovative approaches to diagnosis, monitoring, management, treatment and prevention of viral hepatitis and viral hepatitis associated liver disease.
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New Technologies for Viral Hepatitis STTR (R41/R42)
- Funding Opportunity PA-12-091 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage Small Business Innovation Research (STTR) grant applications from small business concerns (SBCs) that propose to respond to the Combating the Silent Epidemic of Viral Hepatitis: U.S. Department of Health and Human Services Action Plan for the Prevention, Care and Treatment of Viral Hepatitis (Viral Hepatitis Action Plan) which was released on May 12, 2011 (http://www.hhs.gov/ash/initiatives/hepatitis/). SBCs are encouraged to propose STTR grant applications to develop resources, research tools, instrumentations, biomarkers, devices, drugs or new and innovative approaches to diagnosis, monitoring, management, treatment and prevention of viral hepatitis and viral hepatitis associated liver disease.
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HIV Vaccine Research and Design (HIVRAD) Program (P01)
- Funding Opportunity PAR-12-087 from the NIH Guide for Grants and Contracts. Support of multi-component, multi-disciplinary projects that address important scientific questions relevant to AIDS prophylactic vaccine discovery research. Extensive modeling of vaccine concepts in non-human primates may be included.
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Resource Access for the Bridging Interventional Development Gaps Program (X01)
- Funding Opportunity PAR-12-092 from the NIH Guide for Grants and Contracts. The high cost of translating therapeutic discoveries into clinically-available agents can deter the development of promising therapeutics. When private sector resources are limited, BrIDGs in-kind services could help researchers span the gap between the preclinical and clinical stages of therapy development and continue to evaluate agents that may improve the standard of care for patients with a variety of diseases and disorders.The purpose of this Funding Opportunity Announcement (FOA) is to invite investigators to apply for access to government-funded contract resources needed for the preclinical development of therapeutic agents.
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Biomedical and Behavioral Research Innovations to Ensure Equity (BRITE) in Maternal and Child Health (R15)
- Funding Opportunity PAR-12-093 from the NIH Guide for Grants and Contracts. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks to increase the diversity of the pool of researchers involved in health equity research related to NICHD mission areas including infant mortality; Sudden Infant Death Syndrome (SIDS); child, adolescent, and/or adult obesity; uterine fibroids; pediatric and maternal HIV/AIDS prevention; violence prevention; health literacy; and outreach and information dissemination.
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Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21)
- Funding Opportunity PAR-12-094 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the Center to Reduce Cancer Health Disparities (CRCHD) and the Division of Cancer Biology (DCB), at the National Cancer Institute (NCI), invite grant applications from investigators interested in conducting basic research studies into the biological causes and mechanisms of cancer health disparities. These awards will support pilot and feasibility studies, development and testing of new methodologies, secondary data analyses, and innovative mechanistic studies that investigate biological/genetic bases of cancer health disparities. This FOA is also designed to aid and facilitate the growth of a nationwide cohort of scientists with a high level of basic research expertise in cancer health disparities research and to provide resources for those investigators that may need additional support on their path to successfully compete for R01 funding in basic mechanistic research in understanding cancer health disparities.
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Basic Cancer Research in Cancer Health Disparities (U01)
- Funding Opportunity PAR-12-095 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the Center to Reduce Cancer Health Disparities (CRCHD), the Division of Cancer Biology (DCB) and Division of Cancer Prevention (DCP), at the National Cancer Institute (NCI), encourage grant applications from investigators interested in conducting basic, mechanistic research into the biologic/genetic causes of cancer health disparities. These cooperative agreement research awards (U01) will support innovative studies designed to investigate biological/genetic bases of cancer disparities, and may include the development and testing of new methodologies and models, secondary data analyses, and mechanistic studies of identified biological factors associated with cancer disparities, including those related to basic research in prevention strategies. This FOA is also designed to aid and facilitate the development of a nationwide cohort of scientists with a high level of basic research expertise in cancer health disparities research who can develop resources and tools, such as biospecimens, cell lines and methods that are necessary to conduct basic research in cancer health disparities.
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Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21)
- Funding Opportunity PAR-12-096 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA), issued by the Center to Reduce Cancer Health Disparities (CRCHD) and the Division of Cancer Biology (DCB) of the National Cancer Institute (NCI), invites applications by investigators from diverse backgrounds underrepresented in basic and biomedical cancer research. The NIH recognizes a unique and compelling need to promote diversity in the NIH-funded research workforce. The purpose of this FOA is to improve the diversity of the NCI-funded research workforce by supporting and recruiting eligible investigators from groups that have been shown to be underrepresented in the biomedical, clinical, behavioral, and social sciences including individuals from underrepresented racial and ethnic groups, individuals with disabilities, and individuals from socially, culturally, economically, or educationally disadvantaged backgrounds that have recently and demonstrably inhibited their ability to pursue a career in health-related research. This funding opportunity will also provide a bridge to investigators that have completed their research training and may need extra time to develop a research project grant application.
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Ancillary Studies in PREDICT-HD (U01)
- Funding Opportunity PAR-12-197 from the NIH Guide for Grants and Contracts. The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for ancillary studies that will further our understanding of the unique clinical and biomarker signatures of premanifest or prodromal Huntington's disease (HD) through coordination with the NINDS-funded Neurobiological Predictors of Huntington's Disease (PREDICT-HD) study. The PREDICT-HD study is an international 32-site observational study of persons at-risk for HD, and includes clinical and biospecimen resources from 800 premanifest HD participants and 200 healthy control subjects. Extensive clinical data including UHDRS motor examination, cognitive and neuropsychiatric assessments, and structural MRI imaging have been collected over a ten-year time frame, with a subset of these data accessible through the dbGaP website http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000222.v1.p1.
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